Sex-specific cell signaling: the corticotropin-releasing factor receptor model
نویسندگان
چکیده
منابع مشابه
Sex-biased stress signaling: the corticotropin-releasing factor receptor as a model.
Sex differences in the prevalence or severity of many diseases and in the response to pharmacological agents are well recognized. Elucidating the biologic bases of these differences can advance our understanding of the pathophysiology of disease and facilitate the development of treatments. Despite the importance to medicine, this has been an area of limited research. Here, we review physiologi...
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Stress is among the strongest signals promoting neuroplasticity: Stress signals, indicating real or perceived danger, lead to alterations of neuronal function and often structure, designed to adapt to the changed conditions and promote survival. Corticotropin releasing factor (CRF) is expressed and released in several types of neuronal populations that are involved in cognition, emotion and the...
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Constitutive activity, or ligand-independent activity, of mutant G protein-coupled receptors (GPCRs) has been described extensively and implicated in the pathology of many diseases. Using the corticotropin-releasing factor (CRF) receptor and the thrombin receptor as a model, we present a ligand-dependent constitutive activation of a GPCR. A chimera in which the N-terminal domain of the CRF rece...
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ژورنال
عنوان ژورنال: Trends in Pharmacological Sciences
سال: 2013
ISSN: 0165-6147
DOI: 10.1016/j.tips.2013.06.004